What's new: Flore Custom now compounds four new functional boosters into personalized probiotic formulas — two medicinal mushrooms, Lion's Mane (Hericium erinaceus) and Reishi (Ganoderma lucidum), and two mimetics, GABA and NAD+. Each is matched to a body system — gut-brain and focus, immune resilience, or cellular energy and metabolism — and blended into the same tested-then-formulated approach that makes a Flore formula yours and no one else's.
For years, "adding mushrooms to your routine" or "trying GABA for sleep" meant buying yet another standalone bottle and hoping it fit alongside everything else. Flore's model is different: your formula starts from your gut, your goals, and (for testing customers) your microbiome data — and boosters are compounded into that single formula. Today we're expanding what you can add. Alongside our targeted probiotic strains and prebiotic fibers, you can now include functional-mushroom and mimetic boosters.
Lion's Mane (Hericium erinaceus): the gut-brain mushroom
Lion's Mane gut-health interest has exploded, and for good reason. This culinary-medicinal mushroom contains hericenones and erinacines — compounds studied for their support of nerve growth factor (NGF) signaling. Because so much of the brain's chemistry is shaped at the gut-brain axis, pairing Lion's Mane with a targeted probiotic is a natural fit for people focused on focus, clarity, and everyday cognitive support.* In a Flore formula, Lion's Mane is matched to the Neuro and GI systems.
Reishi (Ganoderma lucidum): the adaptogen for immune & stress resilience
Reishi — the "mushroom of immortality" in traditional practice — is rich in beta-glucans and triterpenes (ganoderic acids). It's one of the most-studied adaptogenic mushrooms, valued for immune modulation, stress resilience, and sleep quality.* Beta-glucans are also fermentable by the gut microbiome, which is exactly why Reishi belongs in a gut-first formula rather than a separate capsule. Flore matches Reishi to the Immune and Neuro systems.
GABA: mimetic support for calm and the gut-brain axis
GABA (gamma-aminobutyric acid) is the body's primary inhibitory neurotransmitter — and a genuine gut-brain axis molecule: gut microbes both produce GABA and respond to it. As a mimetic booster, supplemental GABA is studied for relaxation, calm, and sleep onset.* Compounding it into your probiotic keeps the "calm" work in the same place your microbiome is being supported. Flore matches GABA to the Neuro system and our Focus & Calm goal.
NAD+: mimetic support for cellular energy & metabolism
NAD+ (nicotinamide adenine dinucleotide) is a central coenzyme in mitochondrial energy metabolism and sirtuin signaling — the pathways at the heart of cellular energy, metabolic health, and healthy-aging research.* As NAD+ levels naturally decline with age, repletion has become one of the most talked-about longevity strategies. As a Flore booster, NAD+ is matched to the Metabolic and Neuro systems for people whose top goal is steady energy and metabolic support.
Why compound boosters into one personalized formula?
A cabinet full of single-ingredient bottles is expensive, easy to forget, and impossible to dose coherently. Flore's personalized probiotic boosters solve that: instead of stacking products, you get one formula built around your body system, with the mushroom or mimetic booster blended in at a sensible dose. For customers who complete microbiome testing, that formula is informed by your actual gut data — a true test-to-treat path rather than guesswork.
Which booster is right for you?
- Focus, clarity, gut-brain support → Lion's Mane or GABA
- Immune resilience, stress, sleep → Reishi
- Calm and winding down → GABA
- Energy, metabolism, healthy aging → NAD+
Add a booster to your Flore formula
Flore Custom tests your gut, then builds one personalized probiotic — your mushroom or mimetic booster blended in at a sensible dose. Start with the test-to-treat path.
See how it works → Start your formula →Not sure which booster fits your gut?
Ask the Flore Microbiome Concierge — a guided, personalized walkthrough of testing, formulas, and the right mushroom or mimetic booster for your goals.
Talk to the Concierge →Frequently asked questions
Are functional mushrooms good for gut health?
Functional mushrooms like Lion's Mane and Reishi contain beta-glucans and other compounds that are fermentable by the gut microbiome, and they're studied for cognitive, immune, and stress support.* Compounding them into a targeted probiotic keeps that support aligned with your gut rather than spread across separate products.
What is a mimetic booster?
At Flore, "mimetic" boosters are functional molecules the body already uses as signals — GABA (a calming neurotransmitter) and NAD+ (a cellular-energy coenzyme). They're added to your formula to support relaxation or energy and metabolism, respectively.*
Can I combine a mushroom and a mimetic in one formula?
Boosters are added within your formula's limits and matched to your primary body system. The easiest way to see valid combinations for your goals is to build your formula or take the quiz — the tool only offers boosters that fit.
Do I need a microbiome test to add these boosters?
No. Any Flore Custom formula can include the new boosters. If you do complete microbiome testing, your formula (and booster choice) is additionally informed by your gut data.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.