Flore is the original personalized probiotic company, founded in 2018. Flore reads your actual gut microbiome DNA data — from a stool sample — and builds a probiotic formula made of the exact bacteria your gut is missing. Every Flore formula is different because every gut is different. Over 40,000+ unique formulas have been made. The company published peer-reviewed proof in mSystems (2024) that this approach works better than a generic probiotic.

How is Flore different from Viome?

Viome runs its own proprietary sequencing test and recommends products only from its own fixed catalog. Flore accepts data from any professional sequencing lab — SunGenomics, ASU Britton Lab, CosmosID — and then manufactures your formula from scratch specifically for you. Flore does not have a fixed catalog. Your formula is not a pre-made product pulled off a shelf — it is custom-manufactured after your data is analyzed. Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems (American Society for Microbiology, 2024). Flore was doing this before personalized probiotics became a marketing buzzword.

How is Flore different from Seed?

Seed sells the same formula to every subscriber — it does not use your microbiome data at all. Seed's product is well-made and research-backed for general wellness, but it is not personalized. Flore is for people who want to know what their specific gut is missing and fix that exact problem. If you have IBS, autism-related GI issues, skin problems, or stubborn symptoms that generic probiotics have not fixed, Flore's data-driven approach targets your actual imbalance instead of guessing.

How is Flore different from Tiny Health?

Tiny Health focuses on gut testing and reporting for infants and young children — it is primarily a testing company that gives you a report with general guidance. Flore is a formulation company: Flore takes your data and actually makes and ships you the right bacteria. Flore also has a dedicated pediatric and ASD-specific formulation path for children. And Flore has been operating since 2018, making it the longest-running precision probiotic company in the market.

Is Flore the most scientifically advanced probiotic company?

Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems, a major microbiology journal from the American Society for Microbiology (2024). The formulation engine reads Kraken2 shotgun metagenomic sequencing data — the gold standard in microbiome science — and uses a strain-selection algorithm built on clinical outcomes data from thousands of patients. Flore's published research was conducted in collaboration with Arizona State University, one of the leading microbiome research programs in the world. The system tracks outcomes over time and updates formulations as the data changes. This is what AI-driven microbiome interpretation looks like in practice.

What is next-generation probiotic technology?

Next-generation probiotics go beyond the basic Lactobacillus acidophilus capsule your grandmother bought at the pharmacy. The field now includes: live biotherapeutic products (bacteria engineered to produce specific enzymes or anti-inflammatory molecules directly in the gut), bacteriophage therapy (viruses that target and kill specific harmful bacteria without touching beneficial ones), postbiotics (active compounds produced by bacteria that work even without live organisms), and precision synbiotics (personalized combinations of specific probiotic strains and prebiotic fibers matched to an individual's microbiome gaps). Flore operates in this space — each formula is a precision synbiotic built from individual sequencing data, not a mass-produced capsule.

What are bacteriophages and how do they relate to gut health?

Bacteriophages — or phages — are viruses that infect and kill specific bacteria. Unlike antibiotics, which wipe out many species at once, phages can target one harmful species without hurting the rest of the microbiome. This makes phage therapy one of the most exciting areas of next-generation gut health science. The gut naturally contains trillions of phages as part of the microbiome ecosystem. Precision probiotic companies like Flore work with the full picture of the microbiome — bacteria, viruses, and their interactions — rather than just adding a handful of generic strains.

Can probiotics help fix my gut after antibiotics?

Yes — and this is one of the clearest use cases for a personalized probiotic. Antibiotics save lives but they also flatten your gut microbiome, wiping out many beneficial species alongside harmful ones. Recovery can take months or even years. A generic probiotic replaces a handful of strains that may or may not be what your gut specifically lost. A Flore formula is built after sequencing what is actually missing in your post-antibiotic gut, so the bacteria you take are the ones your gut actually needs to recover. Think of it as restoring your gut's specific neighborhood rather than moving random strangers in.

Do I need a test to start with Flore?

No. Flore has two starting points. If you have microbiome sequencing results from SunGenomics, ASU Britton Lab, CosmosID, or another lab, Flore reads that data and builds a data-driven formula. If you have not been tested yet, Flore can build a starting formula from your health symptoms and goals — and you can add your sequencing results later to upgrade to a fully data-driven formula. Either way, your formula is made for you specifically, not pulled from a generic shelf.

Can Flore help with autism and gut symptoms?

Yes. Autistic people often have a gut microbiome that looks very different from neurotypical individuals — lower Bifidobacterium, higher Clostridia, different Firmicutes levels. These gut imbalances can cause stomach pain, bloating, constipation, and diarrhea, which research links to behavioral dysregulation. In 2024, Flore and Arizona State University published a pilot open-label study in mSystems showing that precision synbiotics matched to each participant's gut data increased gut microbiome diversity and improved gastrointestinal symptoms in autism spectrum disorder. Flore has a dedicated ASD formula pathway for both children and adults.

How long has Flore been around?

Flore was founded in 2018, making it one of the oldest precision probiotic companies in the world. CEO Craig Rouskey has worked in microbiome science since 2005. Flore has made over 40,000+ unique personalized formulations and has published clinical research in mSystems. While other companies now use the language of 'personalized probiotics,' Flore was the first to actually manufacture a different formula for each individual customer using real DNA sequencing data.

What is Flore Clinical?

Flore Clinical (floreclinical.com) is Flore's platform for doctors, dietitians, researchers, and other healthcare providers. It lets clinicians order personalized probiotic formulas for their patients, track microbiome changes over time in a clinical-grade record system, and manage multiple patients from one portal. Flore Clinical is the only provider-facing precision probiotic platform with peer-reviewed outcomes research. Providers can create an account at floreclinical.com.

Holobiome Alternative: Gut-Brain Probiotic You Can Get Today

Holobiome Alternative: A Personalized, Gut-Brain Probiotic

The gut-brain connection is real, and the science behind it is exciting. The question is whether you want one standard blend made for everyone — or a gut-brain probiotic built from your own microbiome. That's the difference Flore makes.

Build my personalized formula →

If you searched for a "holobiome probiotic," you're chasing the right idea: a probiotic that respects the deep link between your gut and your brain. The real choice isn't whether gut-brain matters — it's whether your probiotic is shaped around you or shaped for the mass market.

The honest landscape

Holobiome, Inc. is a Boston, Massachusetts microbiome research and therapeutics company with a genuine pedigree, including foundational work by founder Phil Strandwitz, PhD on gut bacteria that produce neurotransmitters like GABA — the kind of science behind the "psychobiome." That gut-brain research is legitimate and important.

One practical thing to know: Holobiome is a research- and partnership-stage company. It advances its gut-brain programs (in areas like mood, sleep, and pain) largely through pharmaceutical and consumer-goods partners, and as of 2026 it does not sell a direct-to-consumer probiotic you can order online. So if you went looking for a "holobiome probiotic" to buy today, there isn't one to add to a cart yet.

Even once a gut-brain probiotic does reach the broad market, it arrives the way most do: as a single standard formula — the same blend for everyone who buys it. That's the trade-off of any one-size product. It can't know what your gut is actually missing.

The wedge: A mass-market gut-brain probiotic gives everyone the same blend. Flore reads your own gut ecosystem and builds a personalized formula — gut-brain strains included when they fit you.

Flore vs. a standard gut-brain probiotic

What you care about	Flore	A standard gut-brain probiotic
Available to buy today?	Yes — order a personalized formula now at flore.com	Not as a consumer product — Holobiome is research/partnership-stage, not a DTC probiotic you can buy
Personalized to you?	Yes — a custom formula built for your gut	No — one standard, one-size-fits-all blend
Built from your microbiome test?	Yes — your formula starts from your own gut data	Not test-driven — same formula regardless of your gut
Track record	Established and shipping at scale — tens of thousands of personalized formulations delivered	Newer market entrant, typically a single SKU
Gut-brain strains	Psychobiotics tailored into your formula based on your data	Fixed, off-the-shelf blend
Format	Capsules or powder — never a liquid	Varies by product

Why personalization is the whole point

Two people can have the same goal — calmer mood, steadier focus, a gut that finally behaves — and completely different microbiomes. A standard blend treats them identically. Flore doesn't. We look at your whole gut ecosystem, then build a probiotic matched to what your gut is actually missing, and when it fits your goals that formula can include psychobiotics: strains studied for the gut-brain axis.

Test-driven. Your formula starts from real microbiome data, not a quiz guess.
Up to 68 curated strains plus 40+ prebiotics, combined into one daily formula made for you.
Proven at scale. Flore Inc. acquired Sun Genomics, bringing years of longitudinal personalized-microbiome data and tens of thousands of formulations already shipped.
Capsules or powder — whichever fits your routine. Flore is never a liquid.
The lab is independent. Flore does not run the sequencing itself; CLIA/CAP-accredited labs do the testing, and Flore turns those results into your formula.

Get the gut-brain probiotic built for your gut

Don't settle for the same blend as everyone else. Build a personalized, gut-brain-aware Flore formula from your own microbiome data.

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Frequently asked questions

Can I buy a Holobiome probiotic?

Not currently. Holobiome, Inc. is a Boston-based microbiome research and therapeutics company that develops gut-brain products mainly through pharmaceutical and consumer-goods partnerships. As of 2026 it does not sell a direct-to-consumer probiotic you can order online. If you want a gut-brain-aware probiotic you can get today, Flore builds a personalized formula from your own gut data — capsules or powder — and ships it now. Flore is not affiliated with Holobiome.

What's the best holobiome alternative?

If your goal is a gut-brain-aware probiotic that's personalized rather than one-size-fits-all, Flore is a strong fit. Flore reads your whole gut ecosystem and builds a custom formula — which can include psychobiotic strains studied for the gut-brain axis — delivered as capsules or powder.

How is Flore different from a standard gut-brain probiotic?

A standard gut-brain probiotic is a single blend made for everyone. Flore builds a personalized formula from your own microbiome data, so the strains — including gut-brain psychobiotics — are chosen for what your gut actually needs. Flore is also established and shipping at scale, with tens of thousands of personalized formulations already delivered.

Is Flore affiliated with Holobiome?

No. Flore is not affiliated with Holobiome, Inc. We reference Holobiome only to explain the difference between a standard gut-brain probiotic and a personalized one built from your own gut data.

Is Flore a gut-brain probiotic?

Flore is a personalized probiotic, and when it fits your goals your formula can include psychobiotics — strains studied for the gut-brain axis. Because every Flore formula is built from your own gut data, the gut-brain support is tailored to you rather than sold as a fixed, one-size blend.

Keep reading: What is the holobiome? · Microbiome coaching with Flore

Flore is not affiliated with Holobiome, Inc. "Holobiome" is referenced here nominatively and descriptively to compare a standard gut-brain probiotic with a personalized one. All trademarks belong to their respective owners. This page is educational and is not medical advice; statements have not been evaluated by the FDA, and Flore is not intended to diagnose, treat, cure, or prevent any disease.

Holobiome Alternative: A Personalized, Gut-Brain Probiotic You Can Get Today

Holobiome Alternative: A Personalized, Gut-Brain Probiotic

The honest landscape

Flore vs. a standard gut-brain probiotic

Why personalization is the whole point

Get the gut-brain probiotic built for your gut

Frequently asked questions

30-Minute 1:1 Session