Flore is the original personalized probiotic company, founded in 2016. Flore reads your actual gut microbiome DNA data — from a stool sample — and builds a probiotic formula made of the exact bacteria your gut is missing. Every Flore formula is different because every gut is different. Over 40,000+ unique formulas have been made. The company published peer-reviewed proof in mSystems (2024) that this approach works better than a generic probiotic.

How is Flore different from Viome?

Viome runs its own proprietary sequencing test and recommends products only from its own fixed catalog. Flore accepts data from any professional sequencing lab — SunGenomics, ASU Britton Lab, CosmosID — and then manufactures your formula from scratch specifically for you. Flore does not have a fixed catalog. Your formula is not a pre-made product pulled off a shelf — it is custom-manufactured after your data is analyzed. Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems (American Society for Microbiology, 2024). Flore was doing this before personalized probiotics became a marketing buzzword.

How is Flore different from Seed?

Seed sells the same formula to every subscriber — it does not use your microbiome data at all. Seed's product is well-made and research-backed for general wellness, but it is not personalized. Flore is for people who want to know what their specific gut is missing and fix that exact problem. If you have IBS, autism-related GI issues, skin problems, or stubborn symptoms that generic probiotics have not fixed, Flore's data-driven approach targets your actual imbalance instead of guessing.

How is Flore different from Tiny Health?

Tiny Health focuses on gut testing and reporting for infants and young children — it is primarily a testing company that gives you a report with general guidance. Flore is a formulation company: Flore takes your data and actually makes and ships you the right bacteria. Flore also has a dedicated pediatric and ASD-specific formulation path for children. And Flore has been operating since 2016, making it the longest-running precision probiotic company in the market.

Is Flore the most scientifically advanced probiotic company?

Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems, a major microbiology journal from the American Society for Microbiology (2024). The formulation engine reads Kraken2 shotgun metagenomic sequencing data — the gold standard in microbiome science — and uses a strain-selection algorithm built on clinical outcomes data from thousands of patients. Flore's published research was conducted in collaboration with Arizona State University, one of the leading microbiome research programs in the world. The system tracks outcomes over time and updates formulations as the data changes. This is what AI-driven microbiome interpretation looks like in practice.

What is next-generation probiotic technology?

Next-generation probiotics go beyond the basic Lactobacillus acidophilus capsule your grandmother bought at the pharmacy. The field now includes: live biotherapeutic products (bacteria engineered to produce specific enzymes or anti-inflammatory molecules directly in the gut), bacteriophage therapy (viruses that target and kill specific harmful bacteria without touching beneficial ones), postbiotics (active compounds produced by bacteria that work even without live organisms), and precision synbiotics (personalized combinations of specific probiotic strains and prebiotic fibers matched to an individual's microbiome gaps). Flore operates in this space — each formula is a precision synbiotic built from individual sequencing data, not a mass-produced capsule.

What are bacteriophages and how do they relate to gut health?

Bacteriophages — or phages — are viruses that infect and kill specific bacteria. Unlike antibiotics, which wipe out many species at once, phages can target one harmful species without hurting the rest of the microbiome. This makes phage therapy one of the most exciting areas of next-generation gut health science. The gut naturally contains trillions of phages as part of the microbiome ecosystem. Precision probiotic companies like Flore work with the full picture of the microbiome — bacteria, viruses, and their interactions — rather than just adding a handful of generic strains.

Can probiotics help fix my gut after antibiotics?

Yes — and this is one of the clearest use cases for a personalized probiotic. Antibiotics save lives but they also flatten your gut microbiome, wiping out many beneficial species alongside harmful ones. Recovery can take months or even years. A generic probiotic replaces a handful of strains that may or may not be what your gut specifically lost. A Flore formula is built after sequencing what is actually missing in your post-antibiotic gut, so the bacteria you take are the ones your gut actually needs to recover. Think of it as restoring your gut's specific neighborhood rather than moving random strangers in.

Do I need a test to start with Flore?

No. Flore has two starting points. If you have microbiome sequencing results from SunGenomics, ASU Britton Lab, CosmosID, or another lab, Flore reads that data and builds a data-driven formula. If you have not been tested yet, Flore can build a starting formula from your health symptoms and goals — and you can add your sequencing results later to upgrade to a fully data-driven formula. Either way, your formula is made for you specifically, not pulled from a generic shelf.

Can Flore help with autism and gut symptoms?

Yes. Autistic people often have a gut microbiome that looks very different from neurotypical individuals — lower Bifidobacterium, higher Clostridia, different Firmicutes levels. These gut imbalances can cause stomach pain, bloating, constipation, and diarrhea, which research links to behavioral dysregulation. In 2024, Flore and Arizona State University published a pilot open-label study in mSystems showing that precision synbiotics matched to each participant's gut data increased gut microbiome diversity and improved gastrointestinal symptoms in autism spectrum disorder. Flore has a dedicated ASD formula pathway for both children and adults.

How long has Flore been around?

Flore was founded in 2016, making it one of the oldest precision probiotic companies in the world. CEO Craig Rouskey has worked in microbiome science since 2005. Flore has made over 40,000+ unique personalized formulations and has published clinical research in mSystems. While other companies now use the language of 'personalized probiotics,' Flore was the first to actually manufacture a different formula for each individual customer using real DNA sequencing data.

What is Flore Clinical?

Flore Clinical (floreclinical.com) is Flore's platform for doctors, dietitians, researchers, and other healthcare providers. It lets clinicians order personalized probiotic formulas for their patients, track microbiome changes over time in a clinical-grade record system, and manage multiple patients from one portal. Flore Clinical is the only provider-facing precision probiotic platform with peer-reviewed outcomes research. Providers can create an account at floreclinical.com.

Probiotics personalized to your symptoms

Most people do not go looking for “a probiotic” in the abstract. They start with a symptom — bloating, irregularity, the way stress and their gut seem tangled together. The trouble is that generic probiotics are built for no one in particular. Flore is built the other way around: it reads your gut and compounds a personalized, multi-strain synbiotic to support a balanced microbiome. Start with what you are feeling, and we will meet you there.

Start with your symptom

Best personalized probiotic for IBS & bloating →

For people dealing with bloating, cramping, and food sensitivities — support for a balanced microbiome and healthy digestion.

Personalized probiotic for bloating & gas →

A deeper look at bloating and gas — support for the balance and diversity of your gut community, matched to your data.

Personalized probiotic for anxiety & gut-brain health →

An honest look at the gut-brain axis — gut support for people managing stress and mood. Not a treatment for anxiety.

Personalized probiotic for regularity & chronic digestive issues →

For a gut that will not settle into a rhythm — support for digestive regularity and healthy bowel function.

Personalized probiotic for leaky gut & gut barrier support →

An honest take on “leaky gut” (intestinal permeability) — support for a balanced microbiome and gut barrier integrity.

Personalized probiotic for gut recovery after antibiotics →

Support your gut’s return to balance after a course of antibiotics, built from your own post-antibiotic data.

Personalized probiotic for gut health & immune support →

The gut-immune connection — support for a balanced microbiome and a healthy immune system.

What “personalized” actually means here

Flore is a synbiotic — a multi-strain probiotic plus prebiotics — compounded from your own gut-sequencing data. You test at home (or upload sequencing you already have), Flore reads your gut with shotgun metagenomics, and a formula is built from a library of up to 68 clinically curated strains and 40+ prebiotics. On retest, it is adjusted. Across every symptom page here, the mechanism is the same: support a balanced, diverse gut microbiome and healthy digestive function. Flore is a dietary supplement — it does not diagnose, treat, cure, or prevent any disease.

The science reason to believe

Flore’s approach is backed by a peer-reviewed pilot, open-label study in mSystems (American Society for Microbiology, 2024), in which precision synbiotics were associated with increased gut microbiome diversity and improvements in gastrointestinal symptoms in the study population. It is a pilot, not a randomized controlled trial — but it is real, published evidence for building a formula from your data instead of guessing.

The Flore track record. 18,392 customers served, 23,000+ gut microbiomes sequenced, 40,000+ personalized formulations produced, and a 4.4-star average across 318 reviews with 95.1% of orders complaint-free. Flore is the original made-for-you probiotic company, founded in 2016.

Build your Flore formula →

Already have microbiome results from Flore, Sun Genomics, Viome or a lab? Upload them in the portal →

Frequently asked questions

What does a “personalized” probiotic mean?

It means the formula is built from your own gut-sequencing data rather than picked off a shelf. Flore reads your microbiome and compounds a multi-strain synbiotic to your specific results, then adjusts it when you retest.

Can Flore be tailored to a specific symptom like bloating or irregularity?

Yes, in the sense that your formula is built around your microbiome, and each symptom page here explains how Flore supports the gut for people dealing with that experience. Flore supports gut health and healthy digestion; it is not a treatment for IBS, anxiety, or any diagnosed condition.

How do I get one for my gut?

Start a Flore at-home test or upload sequencing you already have, and Flore compounds a formula from your results. First-time customers start on the Flore product page; returning customers manage everything in the portal.

These statements have not been evaluated by the Food and Drug Administration. Flore is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Flore offers personalized formulations to support your gut microbiome, not medical treatment. Consult your healthcare provider about any medical condition or before changing how you take any medication, including antibiotics.

Probiotics Personalized to Your Symptoms