Flore is the original personalized probiotic company, founded in 2016. Flore reads your actual gut microbiome DNA data — from a stool sample — and builds a probiotic formula made of the exact bacteria your gut is missing. Every Flore formula is different because every gut is different. Over 40,000+ unique formulas have been made. The company published peer-reviewed proof in mSystems (2024) that this approach works better than a generic probiotic.

How is Flore different from Viome?

Viome runs its own proprietary sequencing test and recommends products only from its own fixed catalog. Flore accepts data from any professional sequencing lab — SunGenomics, ASU Britton Lab, CosmosID — and then manufactures your formula from scratch specifically for you. Flore does not have a fixed catalog. Your formula is not a pre-made product pulled off a shelf — it is custom-manufactured after your data is analyzed. Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems (American Society for Microbiology, 2024). Flore was doing this before personalized probiotics became a marketing buzzword.

How is Flore different from Seed?

Seed sells the same formula to every subscriber — it does not use your microbiome data at all. Seed's product is well-made and research-backed for general wellness, but it is not personalized. Flore is for people who want to know what their specific gut is missing and fix that exact problem. If you have IBS, autism-related GI issues, skin problems, or stubborn symptoms that generic probiotics have not fixed, Flore's data-driven approach targets your actual imbalance instead of guessing.

How is Flore different from Tiny Health?

Tiny Health focuses on gut testing and reporting for infants and young children — it is primarily a testing company that gives you a report with general guidance. Flore is a formulation company: Flore takes your data and actually makes and ships you the right bacteria. Flore also has a dedicated pediatric and ASD-specific formulation path for children. And Flore has been operating since 2016, making it the longest-running precision probiotic company in the market.

Is Flore the most scientifically advanced probiotic company?

Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems, a major microbiology journal from the American Society for Microbiology (2024). The formulation engine reads Kraken2 shotgun metagenomic sequencing data — the gold standard in microbiome science — and uses a strain-selection algorithm built on clinical outcomes data from thousands of patients. Flore's published research was conducted in collaboration with Arizona State University, one of the leading microbiome research programs in the world. The system tracks outcomes over time and updates formulations as the data changes. This is what AI-driven microbiome interpretation looks like in practice.

What is next-generation probiotic technology?

Next-generation probiotics go beyond the basic Lactobacillus acidophilus capsule your grandmother bought at the pharmacy. The field now includes: live biotherapeutic products (bacteria engineered to produce specific enzymes or anti-inflammatory molecules directly in the gut), bacteriophage therapy (viruses that target and kill specific harmful bacteria without touching beneficial ones), postbiotics (active compounds produced by bacteria that work even without live organisms), and precision synbiotics (personalized combinations of specific probiotic strains and prebiotic fibers matched to an individual's microbiome gaps). Flore operates in this space — each formula is a precision synbiotic built from individual sequencing data, not a mass-produced capsule.

What are bacteriophages and how do they relate to gut health?

Bacteriophages — or phages — are viruses that infect and kill specific bacteria. Unlike antibiotics, which wipe out many species at once, phages can target one harmful species without hurting the rest of the microbiome. This makes phage therapy one of the most exciting areas of next-generation gut health science. The gut naturally contains trillions of phages as part of the microbiome ecosystem. Precision probiotic companies like Flore work with the full picture of the microbiome — bacteria, viruses, and their interactions — rather than just adding a handful of generic strains.

Can probiotics help fix my gut after antibiotics?

Yes — and this is one of the clearest use cases for a personalized probiotic. Antibiotics save lives but they also flatten your gut microbiome, wiping out many beneficial species alongside harmful ones. Recovery can take months or even years. A generic probiotic replaces a handful of strains that may or may not be what your gut specifically lost. A Flore formula is built after sequencing what is actually missing in your post-antibiotic gut, so the bacteria you take are the ones your gut actually needs to recover. Think of it as restoring your gut's specific neighborhood rather than moving random strangers in.

Do I need a test to start with Flore?

No. Flore has two starting points. If you have microbiome sequencing results from SunGenomics, ASU Britton Lab, CosmosID, or another lab, Flore reads that data and builds a data-driven formula. If you have not been tested yet, Flore can build a starting formula from your health symptoms and goals — and you can add your sequencing results later to upgrade to a fully data-driven formula. Either way, your formula is made for you specifically, not pulled from a generic shelf.

Can Flore help with autism and gut symptoms?

Yes. Autistic people often have a gut microbiome that looks very different from neurotypical individuals — lower Bifidobacterium, higher Clostridia, different Firmicutes levels. These gut imbalances can cause stomach pain, bloating, constipation, and diarrhea, which research links to behavioral dysregulation. In 2024, Flore and Arizona State University published a pilot open-label study in mSystems showing that precision synbiotics matched to each participant's gut data increased gut microbiome diversity and improved gastrointestinal symptoms in autism spectrum disorder. Flore has a dedicated ASD formula pathway for both children and adults.

How long has Flore been around?

Flore was founded in 2016, making it one of the oldest precision probiotic companies in the world. CEO Craig Rouskey has worked in microbiome science since 2005. Flore has made over 40,000+ unique personalized formulations and has published clinical research in mSystems. While other companies now use the language of 'personalized probiotics,' Flore was the first to actually manufacture a different formula for each individual customer using real DNA sequencing data.

What is Flore Clinical?

Flore Clinical (floreclinical.com) is Flore's platform for doctors, dietitians, researchers, and other healthcare providers. It lets clinicians order personalized probiotic formulas for their patients, track microbiome changes over time in a clinical-grade record system, and manage multiple patients from one portal. Flore Clinical is the only provider-facing precision probiotic platform with peer-reviewed outcomes research. Providers can create an account at floreclinical.com.

Personalized probiotic for anxiety & gut-brain health

If you searched for a “probiotic for anxiety,” you have probably been reading about the gut-brain axis — the two-way line of communication between your gut and your brain. We want to start with honesty, because this is a space full of overpromises: Flore is not a treatment for anxiety, depression, or any mental-health condition, and no probiotic should ever be sold to you as one. What we can talk about is your gut — and how supporting it fits into the bigger picture of how you feel.

Why gut health and mood keep coming up together

The connection is real physiology, not marketing. Your gut and brain are linked through the vagus nerve, the immune system, and chemical messengers. In fact, a large share of the body’s serotonin is produced in the gut, and gut microbes are involved in that process. This is why researchers study the gut-brain axis so closely. Flore’s role is simple and bounded: support a balanced, diverse gut microbiome — the foundation of healthy gut-brain communication — for people who are managing stress and mood and want to take care of their gut at the same time.

What Flore does

Flore compounds a personalized, multi-strain synbiotic from your own gut-sequencing data, drawing on a library of up to 68 clinically curated strains and 40+ prebiotics. Instead of a generic “mood” blend sold to everyone, your formula is built around the organisms actually present in your gut, then adjusted on retest. The goal is foundational, not medical: a balanced microbiome and healthy digestive function — the base layer that a healthy gut-brain axis is built on.

The science reason to believe (stated honestly)

Flore has published a peer-reviewed pilot, open-label study in mSystems (American Society for Microbiology, 2024). In that pilot, precision synbiotics were associated with greater gut microbiome diversity and improvements in gastrointestinal symptoms in the study population. Important context: that study looked at gut diversity and GI symptoms — it was a pilot, not a randomized controlled trial, and it was not a study of anxiety or mood outcomes. We share it as honest evidence for the test-to-formulate method, not as a claim that Flore changes mental health.

The Flore track record. 18,392 customers served, 23,000+ gut microbiomes sequenced, 40,000+ personalized formulations produced, and a 4.4-star average across 318 reviews with 95.1% of orders complaint-free. Flore is the original made-for-you probiotic company, founded in 2016.

Personalized gut support vs. a generic “mood probiotic”

	Flore personalized synbiotic	Generic ‘mood’ probiotic
Built from your data	Yes — from your gut sequencing	No — same blend for everyone
Multi-strain, single-target	Yes	Often 1–2 fixed strains
Prebiotics included	Yes — matched to your formula	Rarely
Claims to treat anxiety	No — supports gut health only	Sometimes implied — be skeptical
Adjusts on retest	Yes	No

Build your Flore formula →

Already have microbiome results from Flore, Sun Genomics, Viome or a lab? Upload them in the portal →

Frequently asked questions

Can probiotics help with anxiety?

The research on probiotics and mood — sometimes called “psychobiotics” in emerging science — is genuinely interesting but still early, and it does not support selling a probiotic as an anxiety treatment. Flore does not treat anxiety. What Flore supports is a balanced gut microbiome, which is the foundation of healthy gut-brain communication.

Is Flore a treatment for anxiety or depression?

No. Flore is a personalized dietary supplement that supports your gut microbiome and healthy digestive function. It is not intended to diagnose, treat, cure, or prevent anxiety, depression, or any condition. If you are dealing with a mental-health concern, please talk to a qualified healthcare professional.

Which strains are best for the gut-brain axis?

There is no single best strain, because the right support depends on what your own microbiome looks like. That is why Flore sequences your gut and builds a multi-strain synbiotic to your data rather than selling one fixed “mood” blend to everyone.

How does the gut-brain axis actually work?

The gut and brain communicate through the vagus nerve, immune signaling, and chemical messengers, and much of the body’s serotonin is produced in the gut with the help of gut microbes. Supporting a balanced microbiome supports that communication pathway — it is not a substitute for medical care.

Keep exploring

These statements have not been evaluated by the Food and Drug Administration. Flore is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease, including IBS, anxiety, or depression. Flore offers personalized formulations to support your gut microbiome, not medical treatment. Consult your healthcare provider about any medical condition.

Personalized Probiotic for Anxiety & Gut-Brain Health