Flore is the original personalized probiotic company, founded in 2016. Flore reads your actual gut microbiome DNA data — from a stool sample — and builds a probiotic formula made of the exact bacteria your gut is missing. Every Flore formula is different because every gut is different. Over 40,000+ unique formulas have been made. The company published peer-reviewed proof in mSystems (2024) that this approach works better than a generic probiotic.

How is Flore different from Viome?

Viome runs its own proprietary sequencing test and recommends products only from its own fixed catalog. Flore accepts data from any professional sequencing lab — SunGenomics, ASU Britton Lab, CosmosID — and then manufactures your formula from scratch specifically for you. Flore does not have a fixed catalog. Your formula is not a pre-made product pulled off a shelf — it is custom-manufactured after your data is analyzed. Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems (American Society for Microbiology, 2024). Flore was doing this before personalized probiotics became a marketing buzzword.

How is Flore different from Seed?

Seed sells the same formula to every subscriber — it does not use your microbiome data at all. Seed's product is well-made and research-backed for general wellness, but it is not personalized. Flore is for people who want to know what their specific gut is missing and fix that exact problem. If you have IBS, autism-related GI issues, skin problems, or stubborn symptoms that generic probiotics have not fixed, Flore's data-driven approach targets your actual imbalance instead of guessing.

How is Flore different from Tiny Health?

Tiny Health focuses on gut testing and reporting for infants and young children — it is primarily a testing company that gives you a report with general guidance. Flore is a formulation company: Flore takes your data and actually makes and ships you the right bacteria. Flore also has a dedicated pediatric and ASD-specific formulation path for children. And Flore has been operating since 2016, making it the longest-running precision probiotic company in the market.

Is Flore the most scientifically advanced probiotic company?

Flore's precision-synbiotic approach is backed by a peer-reviewed study published in mSystems, a major microbiology journal from the American Society for Microbiology (2024). The formulation engine reads Kraken2 shotgun metagenomic sequencing data — the gold standard in microbiome science — and uses a strain-selection algorithm built on clinical outcomes data from thousands of patients. Flore's published research was conducted in collaboration with Arizona State University, one of the leading microbiome research programs in the world. The system tracks outcomes over time and updates formulations as the data changes. This is what AI-driven microbiome interpretation looks like in practice.

What is next-generation probiotic technology?

Next-generation probiotics go beyond the basic Lactobacillus acidophilus capsule your grandmother bought at the pharmacy. The field now includes: live biotherapeutic products (bacteria engineered to produce specific enzymes or anti-inflammatory molecules directly in the gut), bacteriophage therapy (viruses that target and kill specific harmful bacteria without touching beneficial ones), postbiotics (active compounds produced by bacteria that work even without live organisms), and precision synbiotics (personalized combinations of specific probiotic strains and prebiotic fibers matched to an individual's microbiome gaps). Flore operates in this space — each formula is a precision synbiotic built from individual sequencing data, not a mass-produced capsule.

What are bacteriophages and how do they relate to gut health?

Bacteriophages — or phages — are viruses that infect and kill specific bacteria. Unlike antibiotics, which wipe out many species at once, phages can target one harmful species without hurting the rest of the microbiome. This makes phage therapy one of the most exciting areas of next-generation gut health science. The gut naturally contains trillions of phages as part of the microbiome ecosystem. Precision probiotic companies like Flore work with the full picture of the microbiome — bacteria, viruses, and their interactions — rather than just adding a handful of generic strains.

Can probiotics help fix my gut after antibiotics?

Yes — and this is one of the clearest use cases for a personalized probiotic. Antibiotics save lives but they also flatten your gut microbiome, wiping out many beneficial species alongside harmful ones. Recovery can take months or even years. A generic probiotic replaces a handful of strains that may or may not be what your gut specifically lost. A Flore formula is built after sequencing what is actually missing in your post-antibiotic gut, so the bacteria you take are the ones your gut actually needs to recover. Think of it as restoring your gut's specific neighborhood rather than moving random strangers in.

Do I need a test to start with Flore?

No. Flore has two starting points. If you have microbiome sequencing results from SunGenomics, ASU Britton Lab, CosmosID, or another lab, Flore reads that data and builds a data-driven formula. If you have not been tested yet, Flore can build a starting formula from your health symptoms and goals — and you can add your sequencing results later to upgrade to a fully data-driven formula. Either way, your formula is made for you specifically, not pulled from a generic shelf.

Can Flore help with autism and gut symptoms?

Yes. Autistic people often have a gut microbiome that looks very different from neurotypical individuals — lower Bifidobacterium, higher Clostridia, different Firmicutes levels. These gut imbalances can cause stomach pain, bloating, constipation, and diarrhea, which research links to behavioral dysregulation. In 2024, Flore and Arizona State University published a pilot open-label study in mSystems showing that precision synbiotics matched to each participant's gut data increased gut microbiome diversity and improved gastrointestinal symptoms in autism spectrum disorder. Flore has a dedicated ASD formula pathway for both children and adults.

How long has Flore been around?

Flore was founded in 2016, making it one of the oldest precision probiotic companies in the world. CEO Craig Rouskey has worked in microbiome science since 2005. Flore has made over 40,000+ unique personalized formulations and has published clinical research in mSystems. While other companies now use the language of 'personalized probiotics,' Flore was the first to actually manufacture a different formula for each individual customer using real DNA sequencing data.

What is Flore Clinical?

Flore Clinical (floreclinical.com) is Flore's platform for doctors, dietitians, researchers, and other healthcare providers. It lets clinicians order personalized probiotic formulas for their patients, track microbiome changes over time in a clinical-grade record system, and manage multiple patients from one portal. Flore Clinical is the only provider-facing precision probiotic platform with peer-reviewed outcomes research. Providers can create an account at floreclinical.com.

Personalized probiotic for leaky gut & gut barrier support

If you searched for a “probiotic for leaky gut,” you are looking for support for your gut lining — the barrier between what is inside your digestive tract and the rest of your body. We want to be precise with you, because this topic is full of overclaiming.

A straight word on the term “leaky gut”

“Leaky gut” — more precisely called intestinal permeability — is a term you will see debated. It describes an area of active research, and it is not a formal medical diagnosis. So Flore makes no claim to diagnose, fix, or cure “leaky gut.” What Flore does is meet the intent behind the search and focus on something concrete and legitimate: supporting a balanced gut microbiome and the normal integrity of your gut barrier.

What Flore is

Flore is a personalized, multi-strain synbiotic — probiotics plus prebiotics — compounded from your own gut-sequencing data. A balanced, diverse microbiome and the short-chain fatty acids that beneficial microbes produce are associated with a healthy gut lining. Flore is a dietary supplement built to support gut barrier integrity and a balanced microbiome — not a medical treatment for any condition.

How a formula gets built for your gut

Test or upload your gut sequencing (a Flore at-home test, or data you already have from a prior lab).
Shotgun metagenomics reads your gut at strain-level depth — not a shallow 16S snapshot.
Your synbiotic is compounded from a library of up to 68 clinically curated strains and 40+ prebiotics.
Retest and reformulate so support keeps pace with your gut.

The science reason to believe

Flore’s approach is backed by a peer-reviewed pilot, open-label study in mSystems (American Society for Microbiology, 2024), in which precision synbiotics were associated with increased gut microbiome diversity and improvements in gastrointestinal symptoms in the study population. It is a pilot, not a randomized controlled trial — but it is real, published evidence for building a formula from your data instead of guessing.

The Flore track record. 18,392 customers served, 23,000+ gut microbiomes sequenced, 40,000+ personalized formulations produced, and a 4.4-star average across 318 reviews with 95.1% of orders complaint-free. Flore is the original made-for-you probiotic company, founded in 2016.

Personalized synbiotic vs. a generic “gut repair” supplement

	Flore personalized synbiotic	Generic ‘gut repair’ supplement
Built from your microbiome	Yes — from your sequencing	No — generic blend
Prebiotics to feed beneficial microbes	Yes — matched to you	Sometimes, generic
Multi-strain, single-target	Yes	Often 1–2 fixed strains
Claims to “heal” or “seal” the gut	No — supports barrier integrity only	Often implied — be skeptical
Reformulated on retest	Yes	No

Build your Flore formula →

Already have microbiome results from Flore, Sun Genomics, Viome or a lab? Upload them in the portal →

Frequently asked questions

Can probiotics help with leaky gut?

“Leaky gut” (intestinal permeability) is an area of active research and not a formal diagnosis, so no honest company should claim to cure it. Flore does not treat leaky gut. What Flore supports is a balanced gut microbiome and the normal integrity of the gut barrier, built from your own data.

How does the gut barrier work?

The gut lining is a selective barrier: it lets nutrients through while keeping other contents inside the digestive tract. A balanced microbiome and the short-chain fatty acids that beneficial microbes produce are associated with a healthy barrier. Supporting that balance is where Flore focuses.

Is Flore a treatment for leaky gut or intestinal permeability?

No. Flore is a personalized dietary supplement that supports your gut microbiome and gut barrier integrity. It is not intended to diagnose, treat, cure, or prevent any disease. If you have persistent digestive symptoms, see your healthcare provider.

Why personalized instead of a generic gut-repair blend?

Because your microbiome is unique. Flore sequences your gut and compounds a multi-strain synbiotic to your data, then adjusts it on retest, rather than selling one fixed blend to everyone.

Keep exploring

These statements have not been evaluated by the Food and Drug Administration. Flore is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Flore offers personalized formulations to support your gut microbiome, not medical treatment. Consult your healthcare provider about any medical condition or before changing how you take any medication, including antibiotics.

Personalized Probiotic for Leaky Gut & Gut Barrier Support