Maybe it's been a few weeks. Maybe a few months. Things are changing, and mostly that's the point. You made a decision about your health, and you're living with it on purpose.
And then there's the other part. The part you bring up quickly, near the end of the appointment, almost like an afterthought. The bloating. The mornings your stomach feels like it belongs to someone else. The days you plan around a bathroom, or around not needing one at all.
You're not imagining it. Nausea, diarrhea, constipation and stomach pain are among the most common side effects listed in the prescribing information for semaglutide. Most people on a GLP-1 know exactly what you mean.
What's harder to find is anyone asking the next question: what's going on in your gut?
Your gut has its own population
Your digestive tract is home to trillions of microbes. Together they're called your gut microbiome. They help break down what you eat, and the mix is different in every person.
A GLP-1 changes how much you eat and how quickly food moves through you. That changes what your microbes have to work with.
Researchers have started looking at this. A 2017 study of people taking liraglutide reported changes in their gut microbiome. A 2025 systematic review found the evidence is still early: small studies, many of them in animals, with results that vary from person to person.
So here's the honest version. Nobody can tell you in advance what your GLP-1 is doing to your gut. Which is exactly why it's worth looking.
See how the Flore GLP Program works →
Looking first, then building
Most products made for people on a GLP-1 are one formula for everyone, chosen without ever looking at you.
Flore starts from the other end. The Flore GLP Program begins with two at-home tests that ship on day one: a gut microbiome test and an organic acids (OATS) urine test. CLIA-certified partner labs run the analysis. Your organic acids results come back about two weeks after you return the sample; your microbiome results three to four weeks after you send in the kit.
Then Flore builds your probiotic formula from your results. Three months of it, made for your gut, not someone else's.
What this is, and what it isn't
Flore doesn't sell GLP-1 medications, and doesn't advise on them. That conversation belongs with your prescriber.
This is about the part of the picture that usually goes unmeasured. Flore has spent 10 years building personalized formulas for more than 18,700 people, and every one of them started the same way: by looking first.
You already made one deliberate decision about your health. This one can be just as deliberate. Find out what's going on in your gut, then decide what to do about it.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Flore does not sell GLP-1 medications or peptides. Talk to your prescriber before changing any medication.
Sources: Wegovy (semaglutide) prescribing information, Adverse Reactions. Wang et al., liraglutide and the gut microbiome in type 2 diabetes (PMID 30815546). Systematic review of GLP-1 analogues and gut microbiota, 2025 (PMC12029897).