At-Home Gut Microbiome Test (WGS) — Test to Treat
Flore Test to Treat is an at-home gut microbiome test that does what a report can’t: whole-genome (shotgun) sequencing maps your gut at strain level, and then Flore manufactures a personalized probiotic and prebiotic program matched to your results — then retests to confirm it is working. Most gut tests stop at a PDF and point you toward other brands. Flore closes the loop from test to treatment.
In short: A standard gut test tells you what is wrong. Flore is a test-to-treat program: it sequences your microbiome with whole-genome analysis, builds and ships a probiotic + prebiotic regimen matched to your gut, links you to other support where needed, and retests every 6 months to track progress — for $658.50 (about $110/month), down from $753.
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Test to treat: the whole loop, not half of it
Most at-home gut tests do one thing: they sequence your stool and hand you a report with generic suggestions. Flore runs the full loop:
- Test — an at-home stool kit; your DNA is sequenced with whole-genome shotgun metagenomics at a CLIA-certified, CAP-accredited lab.
- Analyze — strain-level identification plus functional-gene analysis, benchmarked against 23,447 sequenced microbiomes.
- Treat — Flore manufactures a personalized probiotic and prebiotic program matched to your results (and links you to other products where they help).
- Retest — every 6 months, so you can see whether your gut is actually moving in the right direction.
Testing without treatment is half an answer. The reason people ask “what is the best at-home gut test” and still feel stuck is that the report was the finish line. With Flore, the report is the starting line.
What “whole-genome, full analysis” actually means
Not all gut tests read your microbiome the same way, and the method decides what the results can tell you:
- Whole-genome shotgun metagenomics (Flore) — sequences all the DNA in your sample, resolving bacteria to the strain level and reading their functional genes (what your microbes can actually do).
- 16S rRNA sequencing — reads one marker gene; cheaper, but usually stops at the genus level and cannot see function.
- qPCR panels (e.g. GI-MAP) — look only for a fixed list of targets they were designed to find.
- Metatranscriptomic RNA (e.g. Viome) — reads activity, then matches you to a fixed catalog of supplements.
Flore uses the deepest of these — whole-genome, full-analysis sequencing — because a personalized formula is only as good as the resolution of the data behind it.
Flore vs Viome vs Tiny Health vs GI-MAP
| Flore Test to Treat | Viome | Tiny Health | GI-MAP | |
|---|---|---|---|---|
| Method | Whole-genome shotgun (WGS) | Metatranscriptomic RNA | Metagenomic sequencing | qPCR targeted panel |
| Gives a report | Yes | Yes | Yes | Yes |
| Manufactures your personalized formula | Yes — probiotics + prebiotics matched to you | No — picks from a fixed catalog | No — recommends other brands | No — clinician interprets |
| Retests to confirm progress | Yes — every 6 months | — | — | — |
| Own peer-reviewed clinical study | Yes (mSystems, 2024) | — | — | Diagnostic assay |
| Best for | Adults with chronic or multi-system gut issues | General wellness | Babies, family, prenatal, vaginal | Practitioner-ordered |
| Model | 6-month program, $658.50 (~$110/mo) | Test + supplement subscription | Membership (~$399/yr) | Lab test via provider |
The pattern is simple: Viome, Tiny Health, and GI-MAP all test and recommend. Flore is the one that tests and treats — it manufactures the formula and measures whether it worked.
Who it’s for
Flore Test to Treat is built for adults with a real, ongoing gut complaint — bloating, irregularity, IBS-like symptoms, skin that reacts to the gut, low energy, recurring imbalances — who are done guessing and want a formula built from their own data. If you want a simple wellness snapshot or a baby/family test, other tools may fit better; if you want a test that ends in an actual treatment, this is it. Already have recent whole-genome results? Flore also offers bring-your-own-test personalized formulas in 3-, 6-, and 12-month terms.
The evidence
Flore is the only personalized-probiotic program in this category with its own peer-reviewed clinical study of its synbiotics (mSystems, American Society for Microbiology, 2024). Formulas are informed by 23,447 sequenced microbiomes, sequencing is run by CLIA-certified, CAP-accredited laboratories using validated Lab-Developed-Tests, and Flore is rated 4.4 on Trustpilot across 318 verified reviews.
What it costs
The Flore Test to Treat program is $658.50 — discounted from $753 — which works out to about $110 per month. It is a 6-month program that renews every six months, and it includes your whole-genome gut test, your personalized probiotic and prebiotic regimen, and your 6-month retest.
Start your Test to Treat program →
Frequently asked questions
What is a test-to-treat gut program?
A test-to-treat gut program sequences your gut microbiome and then delivers an actual treatment based on the results — not just a report. Flore sequences your gut with whole-genome analysis, manufactures a personalized probiotic and prebiotic regimen matched to your data, and retests to confirm progress. Most gut tests stop at the report; a test-to-treat program continues to the treatment and follow-up.
Does Flore give you a personalized probiotic, or just a report?
Both. Flore delivers a full microbiome report and then manufactures a personalized probiotic and prebiotic program matched to your results. This is the main difference from tests like Viome and Tiny Health, which provide a report and recommendations but do not manufacture your formula.
What is whole-genome (shotgun) sequencing for the gut?
Whole-genome shotgun metagenomics sequences all the DNA in your stool sample, identifying bacteria to the strain level and reading their functional genes. It is deeper than 16S rRNA sequencing (which usually stops at genus) and broader than qPCR panels (which only look for a fixed target list), so it supports a more precisely matched formula.
How much does the Flore gut test cost?
The Flore Test to Treat program is $658.50 (discounted from $753), about $110 per month. It is a 6-month program that includes the whole-genome gut test, a personalized probiotic and prebiotic regimen, and a 6-month retest. Bring-your-own-test personalized formulas are also available in 3-, 6-, and 12-month terms.
Flore vs Viome vs Tiny Health — what is the difference?
Viome uses RNA sequencing and matches you to supplements from a fixed catalog. Tiny Health uses metagenomic sequencing and recommends third-party products, with a focus on babies and family health. Flore uses whole-genome sequencing and manufactures your own personalized probiotic and prebiotic program, then retests — a full test-to-treat loop rather than test-and-recommend.
Is the gut test done by a certified lab?
Yes. Sequencing is performed by CLIA-certified, CAP-accredited laboratories running validated Lab-Developed-Tests — a higher bar than the research-use-only testing much of the microbiome category relies on.